DAILY: Vitamin D, Aspirin, Exercise, Low Saturated Fat Foods Study in Colorectal Cancer Patients With Minimal Residual Disease

This study is designed for colorectal cancer patients with detectable circulating tumor DNA (ctDNA) in the blood and no evidence of cancer on imaging. ctDNA testing is performed with the Natera Signatera assay.

Lifestyle Interventions:

-Daily aspirin supplementation

-Daily vitamin D supplementation

-Plant based/low saturated fat diet

-Exercise (150 minutes of moderate activity weekly)

This study is designed for colorectal cancer patients with detectable circulating tumor DNA (ctDNA) in the blood and no evidence of cancer on imaging. ctDNA testing is performed with the Natera Signatera assay. Positive ctDNA patients will adhere to the following lifestyle interventions for 3 months:

  • Aspirin supplementation
  • Vitamin D supplementation
  • Plant based/low saturated fat diet
  • Physical activity (150 minutes of moderate activity weekly)

Patients will receive a Fitbit for activity tracking, a formal dietary counseling session prior to starting interventions, and twice monthly telephone coaching sessions throughout the duration of the trial to promote compliance.

Key Eligibility Criteria

  • Patients must have detectable ctDNA levels in the blood without evidence of disease on imaging.
  • Patients must have completed all standard of care treatment
  • Other standard of care eligibility criteria related to performance status, lab values, and other chronic illnesses will need to be reviewed.

See ClinicalTrials.gov for more details:

Study Record