Benny Johnson, DO, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses strategies to enhance the efficacy of immunotherapies in microsatellite stable (MSS) colorectal cancer, a subtype that is typically immunologically cold. Targeting pathways such as VEGF and developing TKIs may provide a path for immunotherapies to be efficacious. Cellular therapies such as CAR-T cell therapies and neoantigen vaccines with checkpoint inhibition additionally represent promising strategies on the horizon. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.
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